CONIOSULPHIDES AND THEIR DERIVATIVES, METHOD FOR T

专利名称：CONIOSULPHIDES AND THEIR DERIVATIVES,

METHOD FOR THEIR PRODUCTION ANDUSE AS MEDICAMENTS

发明人：VERTESY, LASZLO,EHRLICH, KLAUS,KURZ,

MICHAEL,SEGETH, MARIAN, PAUL,TOTI,LUIGI

申请号：EP02777014.8申请日：20020906公开号：EP1474440A2公开日：20041110

摘要：Compounds of the type referred to coniosulfuros farnesyl thiopeptide offormula I wherein R1 is H, alkyl of C1 - C6, alquenilo, alquinilo C2 - C6 C6 C10 alkyl, arylaryl (C1 - C4 -, NH2, NH alkyl of C1 - C6NH - alquenilo C2 - C6 optionally replaced with o= o or c1-c6 alkyl, or alquenilo - C2 - C6, among others; R2 is H, Methyl, Ethyl, Isopropyl,n-butyl,Isobutyl; R3 is 1 to 10 protected amino acids with a Group Co - C1 - C6 alkyl; R4 isH, alkyl of C1 - C6, co alkyl C1C - 6; p is 0 - 2; except compounds where R1,R2 and R4 areh; R3 is COCH3; p is 0 - 1.It also relates to a process for Preparation by fermentation withconiochaeta ellipsoidae Udagawa or a Variant or Mutant; the use of a tetramico acidderivative as coniosetina.The compounds inhibit the interaction of amyloid precursorprotein and fe - 65 can be useful for the treatment of degenerative neuropathies orAlzheimer's disease

申请人：AVENTIS PHARMA DEUTSCHLAND GMBH

地址：Brüningstrasse 50 65929 Frankfurt am Main DE

国籍：DE

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