Benzothiophene derivatives, their preparation and

专利名称：Benzothiophene derivatives, their

preparation and use as urokinase inhibitors

发明人：Akito Tanaka,Hiroaki Mizuno,Minoru Sakurai申请号：US09/147812申请日：19990312公开号：US06093710A公开日：20000725

摘要：A compound of the formula ##STR1## in which R.sup.1 is hydrogen, lower alkyl,optionally substituted ar(lower)alkyl, cyclo(lower) alkyl(lower) alkyl, protectedcarboxy)lower)alkyl, carboxy)lower)alkyl, hydroxy(lower) alkyl, optionally substitutedlower alkylcarbamoyl(lower) alkyl, lower alkylthio(lower)alkyl, carboxy(lower)alkanoyl,protected carboxy(lower) alkanoyl, aroyl, lower alkanoyl, or optionally substitutedarylcarbamoyl(lower)alkyl,

R. sup.2 is hydrogen, carboxy, protected carboxy, formyl or N-(lower)alkyl- N-(lower)alkoxycarbamoyl,

R.sup.3 is hydrogen or amidino-protective group,< P>

A is lower alkylene or carbonyl,

X is ##STR2## Y is --S- - or --SO.sub.2 --, Z is --S-- or --O--,

< P>or pharmaceutically acceptable salts thereof

which is useful as a medicament.

申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

代理机构：Oblon, Spivak, McClelland, Maier & Neustadt, P

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