专利名称：Gene Therapy Using TGF-beta
发明人：Moon Jong NOH,Kyoung Ae Kang,Kwan Hee
Lee
申请号：US12014715申请日：20080115
公开号：US20080226611A1公开日：20080918
专利附图：
摘要：The subject invention is related to a cell-mediated gene therapy treatment fororthopedic disease using a member belonging to the transforming growth factor-β (TGF-β) superfamily. TGF-β gene therapy as a new treatment method for degenerative arthritis
is demonstrated. After transfection of TGF-β cDNA expression vectors into fibroblasts(NIH 3T3-TGF-β1), the cells were injected into rabbit achilles tendon and knee joints withartificially-made cartilage defects. Intratendinous injections were performed todetermine the optimal concentration for in vivo expression. Partially defected cartilagemodel was made to simulate degenerative arthritis of the knee joint. The partial cartilagedefect treated with the cell-mediated gene therapy procedure was covered by newlyformed hyaline cartilage which indicates that the cells survived and stimulated matrixformation in this area. Completely denuded cartilage areas were covered by fibrouscollagen.
申请人：Moon Jong NOH,Kyoung Ae Kang,Kwan Hee Lee
地址：Rockville MD US,Kyunggi-Do KR,Rockville MD US
国籍：US,KR,US
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