TRIPTOLIDE DERIVATIVES AND THEIR USE

专利名称：TRIPTOLIDE DERIVATIVES AND THEIR USE发明人：LI, YUANCHAO,ZUO, JIANPING,ZHANG,

FAN,ZHOU,RU,DING, JIAN

申请号：CN0300095申请日：20030128

公开号：WO2004058770A8公开日：20050714

摘要：Triptolide derivatives of Formula (I), their pharmaceutically receptable salts andoptical isomers, Formula (I), (wherein, C5 and C6 connect with each other by a C-C singlebond or double bond; when C5 and C6 are connected with C-C single bond, X and Yrepresents independently hydrogen, oxygen, hydroxy, halogen, lower alkyloxy, loweralkylamino, mercapto, lower alkylthio, the group of formula -OCOR, -OSO2OR or -OPO(OH)2, each of which is attached to C5 and C6, R represents -(CH2)nCO2Na, -(CO2)nCO2K, or -(CH2)nCH3, wherein n = 1-6; Z represents hydrogen, oxygen, hydroxy,halogen, lower alkyloxy, lower alkylamino, mercapto, lower alkylthio, the group offormula -OCOR, -OSO2OR or -OPO(OH)2, each of which is linked at C14-position, Rrepresents -(CH2)nCO2Na, -(CO2)nCO2K, or -(CH2)nCH3, wherein n = 1-6; wherein, the \"__\"linked with X, Y, and Z represents \"(a) \" or \"(b)\" , provided that X and Y cannot both behydrogen atom at the same time), the methods for preparing them and their use asantiphlogistic agent, immunosuppressive agent or therapeutic agent for other relateddiseases.

申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OFSCIENCES,LI, YUANCHAO,ZUO, JIANPING,ZHANG, FAN,ZHOU,RU,DING, JIAN,SHANGHAI

PHARMACEUTICAL (GROUP) CO., LTD.

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